کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1918830 1047976 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms
چکیده انگلیسی

ObjectiveTo evaluate the benefits and risks of hormone replacement therapy (HRT) combined with methyltestosterone (MT) in postmenopausal women with sexual dysfunction.DesignThis study was a randomized, double-blind, placebo-controlled and crossover trial. Eighty-five women using HRT were divided into four treatment groups: GI–HRT plus placebo for 4 months; GII–HRT plus MT 2.5 mg/day for 4 months; GIII–HRT plus placebo for 2 months and then replaced with HRT plus MT 2.5 mg/day for 2 months; GIV–HRT plus MT 2.5 mg/day and then replaced with HRT plus placebo for 2 months. Blood was collected at baseline, after 2 months (T1) and 4 months (T2) of treatment for hormone determinations of estradiol, FSH, total and free testosterone, GOT, GPT, glucose, total and fractions of cholesterol and triglycerides. All participants answered clinical questions and a validated questionnaire of modified McCoy's sex scale.ResultsThe association of HRT with MT 2.5 mg/day did not significantly change liver enzymes or increase cardiovascular risk factors. The patients of GII, GIIII and GIV when using MT presented amelioration of sex symptoms, mainly satisfaction and desire (p < 0.01); however, GIII at T1 (1.3 ± 0.3) presented similar problem score results as compared to GIII at T2 (1.5 ± 0.6).ConclusionAll data suggest that combined HRT-androgen therapy may be beneficial for postmenopausal women receiving HRT who continue to complain of sexual difficulties or for postmenopausal women with sexual complaints who are not undergoing estrogen therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 56, Issue 1, 20 January 2007, Pages 69–77
نویسندگان
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