کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919003 1047987 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dry eye in post-menopausal women using hormone replacement therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Dry eye in post-menopausal women using hormone replacement therapy
چکیده انگلیسی

PurposeTo evaluate the effect of hormone replacement therapy (HRT) on dry eye in post-menopausal women.MethodsForty post-menopausal women with dry eye (20 patients, group 1) and without dry eye (20 patients, group 2), and planning to receive HRT (estrogen plus progesterone), were recruited as the study groups. Forty age-matched untreated women were enrolled as controls (group 3 with dry eye, 5 patients; group 4 without dry eye, 35 patients). Patients having at least one of the symptoms (dryness, itching, photophobia, foreign body sensation, and tearing) together with two of the tests with positive results for dry eye (tear film break-up time (BUT), fluorescein staining of the cornea, analysis of the meibomian gland, and Schirmer I test) in both eyes were considered dry eye positive. Hormonal assay for follicle stimulating hormone, luteinizing hormone, estradiol, and free testosterone was performed. Dry eye statuses in the groups were evaluated statistically.ResultsFour patients with incomplete follow-up data were excluded. HRT use increased estrodiol levels in the groups. Mean ages of patients (50.2 ± 4.8 and 50.7 ± 3.9 years, and 50.0 ± 4.6 and 53.0 ± 3.9 years) were similar (p = 0.67). Duration of menopause in groups 1 and 2 (3.2 ± 2.2 and 1.4 ± 1.2 years; p = 0.01), and in groups 3 and 4 (3.0 ± 1.6 and 1.7 ± 1.3 years; p = 0.014) were different. At the third month examinations, all of the patients in group 1, and 11 patients (61.1%) in group 2 had dry eye (p = 0.003).ConclusionDuration of menopause and use of HRT may increase the incidence of dry eye in post-menopausal woman.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 56, Issue 3, 20 March 2007, Pages 257–262
نویسندگان
, , , , , ,