Contrasting effects of estradiol, testosterone and of a black cohosh extract on density, mechanical properties and expression of several genes in the metaphysis of the tibia and on fat tissue of orchidectomized rats

It is concluded that the effects of E2 and T in the bone and in fat tissue are dissimilar in that only E2 extract but not T increase bone stability and decrease fat accumulation. The CR extract BNO 1055 had mild antiosteoporotic and lipolytic or antilipotropic effects which may make these extracts useful to prevent osteoporosis in males.