کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1920443 | 1048695 | 2015 | 5 صفحه PDF | دانلود رایگان |
• Cognitively intact Parkinson's disease patients showed larger hippocampal volumes than controls.
• Shape changes in the right nucleus accumbens in the tremor dominant PD patients may be an imaging biomarker for PD subtype.
• Morphologic changes in the hippocampus and NAcc may be related to dopaminergic replacement on the mesolimbic pathway.
• Further studies are needed to determine clinical significance of volumetric changes.
BackgroundParkinson's disease (PD) is a common neurodegenerative disorder associated with gray matter atrophy. Cortical atrophy patterns may further help distinguish between PD motor subtypes. Comparable differences in subcortical volumes have not been found.MethodsTwenty-one cognitively intact and treated PD patients, including 12 tremor dominant (TD) subtype, Nine postural instability gait dominant (PIGD) subtype, and 20 matched healthy control subjects underwent 3.0 T high-resolution structural MRI scanning. Subcortical volumetric analysis was performed using FreeSurfer and shape analysis was performed with FIRST to assess for differences between PD patients and controls and between PD subtypes.ResultsNo significant differences in subcortical volumes were found between motor PD subtypes, but comparing grouped PD patients with controls revealed a significant increase in hippocampal volume in PD patients (p = 0.03). A significant shape difference was detected in the right nucleus accumbens (NAcc) between PD and controls and between motor subtypes. Shape differences were driven by positive deviations in the TD subtype. Correlation analysis revealed a trend between hippocampal volume and decreasing MDS-UPDRS (p = 0.06).ConclusionWhile no significant differences in subcortical volumes between PD motor subtypes were found, increased hippocampal volumes were observed in PD patients compared to controls. Right NAcc shape differences in PD patients were driven by changes in the TD subtype. These unexpected findings may be related to the effects of chronic dopaminergic replacement on the mesolimbic pathway. Further studies are needed to replicate and determine the clinical significance of such morphologic changes.
Journal: Parkinsonism & Related Disorders - Volume 21, Issue 5, May 2015, Pages 536–540