Restless legs syndrome in Parkinson's disease

SummaryThe Restless legs syndrome (RLS) and Parkinson's disease (PD) are two disorders that can co-exist, whether or not they share a common pathophysiology. If, and to what extent RLS and PD share the same pathophysiology, is still under debate. Sleep disturbances are prevalent in PD, and as PD progresses, nocturnal disturbances become even more evident, in association not only with motor symptoms but also with non-motor symptoms. Alertness to, and recognition of, RLS in PD patients with sleep disorders could improve customized treatment and quality of life of these patients. In this article the prevalence of RLS in PD, the clinical profile of RLS in PD, the PD profile of patients with RLS, RLS mimics specifically related to PD and impact of RLS in PD will be reviewed.