کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1921483 1048773 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic variation of Omi/HtrA2 and Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Genetic variation of Omi/HtrA2 and Parkinson's disease
چکیده انگلیسی

Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n = 2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 7, November 2008, Pages 539–543
نویسندگان
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