کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1921719 | 1048780 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Partial agonist actions at dopamine D2L receptors are modified by co-transfection of D3 receptors: Potential role of heterodimer formation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Partial agonist actions at dopamine D2L receptors are modified by co-transfection of D3 receptors: Potential role of heterodimer formation Partial agonist actions at dopamine D2L receptors are modified by co-transfection of D3 receptors: Potential role of heterodimer formation](/preview/png/1921719.png)
چکیده انگلیسی
The effects of aripiprazole, S33592, bifeprunox, N-desmethylclozapine and preclamol acting as partial agonists on recombinant D2L and D3 receptors expressed both separately and concomitantly in COS-7 cells are evaluated here. Aripiprazole, S33592, bifeprunox, N-desmethylclozapine and preclamol behave as partial agonists on D2L receptors coupled with adenylyl cyclase, but they behave as antagonists on co-expression of D3 with D2L receptors. These data raise the intriguing hypothesis that antipsychotic actions of “partial agonists” such as aripiprazole may not reflect inefficient stimulation of D2 and/or D3 receptors but, by analogy with other antipsychotics, may instead represent a blockade of D2/D3 heterodimers (and/or D3 receptors) that are “weakly” coupled to transduction mechanisms postsynaptically of the dopaminergic pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Supplement 2, July 2008, Pages S139-S144
Journal: Parkinsonism & Related Disorders - Volume 14, Supplement 2, July 2008, Pages S139-S144
نویسندگان
Roberto Maggio, Francesca Novi, Mario Rossi, Giovanni U. Corsini, Mark J. Millan,