کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1922002 | 1048791 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study](/preview/png/1922002.png)
چکیده انگلیسی
We were interested to know if chronic l-DOPA treatment in Parkinson's disease (PD) patients could restore impairment of the intracortical excitability, when this difference could occur, and if it was related to the total daily dose of l-DOPA. Twelve patients with early PD were studied using paired transcranial magnetic stimulation before the administration of l-DOPA, and then after 3, 6, and 12 months of l-DOPA treatment. The level of disturbed intracortical excitability strongly correlated with the total daily dose of l-DOPA. The level of cortical excitability in PD patients seems to be indirectly related to the nigro-striatal functioning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 13, Issue 8, December 2007, Pages 489-494
Journal: Parkinsonism & Related Disorders - Volume 13, Issue 8, December 2007, Pages 489-494
نویسندگان
Martin BareÅ¡, Petr KaÅovský, Ivan Rektor,