کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1922124 | 1048796 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Three sisters with very-late-onset major depression and parkinsonism
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Three sisters with very-late-onset major depression and parkinsonism Three sisters with very-late-onset major depression and parkinsonism](/preview/png/1922124.png)
چکیده انگلیسی
Familiar Parkinson's disease has an age of onset from the second to the sixth decade, whereas Wilson's disease (WD) usually presents in the first decade of life. We studied three sisters with a form of very-late-onset major depression and parkinsonism with probable linkage to ATP7B gene. Molecular studies demonstrated a nucleotide deletion at the 5â²UTR region in a single allele of ATP7B gene. They did not have a family history of WD, or markers indicative for copper deposition in peripheral tissues. We suggest that single allele mutations of ATP7B gene may confer a susceptibility for late-onset major depression and parkinsonism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 13, Issue 2, March 2007, Pages 122-125
Journal: Parkinsonism & Related Disorders - Volume 13, Issue 2, March 2007, Pages 122-125
نویسندگان
GianPietro Sechi, Giovanni Antonio Cocco, Alessandra Errigo, Luca Deiana, Giulio Rosati, Virgilio Agnetti, Kay Stephen Paulus, Giovanni Mario Pes,