کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1922861 1535842 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative stress influence on renal dysfunction in patients with obstructive jaundice: A case and control prospective study
ترجمه فارسی عنوان
تأثیر استرس اکسیداتیو بر اختلال عملکرد کلیوی در بیماران مبتلا به یرقان انسدادی: یک مورد و شاهد مطالعه آینده نگر
کلمات کلیدی
OJ، یرقان انسدادی؛ ARF، نارسایی حاد کلیوی؛ LPO، lipoperoxides؛ GSH، گلوتاتیون؛ CAT، کاتالاز؛ SOD، سوپراکسید دیسموتاز؛ GSH-PX، گلوتاتیون پراکسیداز؛ MDRD، تغییر رژیم غذایی در بیماری کلیوی. GFR، میزان فیلتراسیون گلومرولی؛ MDA،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Obstructive jaundice was associated to a decreased glomerular filtration rate.
• Renal impairment was more frequent in jaundiced patients than in healthy subjects.
• LPO levels were higher in jaundiced patients than in healhy subjects, with highest levels related to malignant ethiology.
• Renal function was affected by the intensity of the biliary obstruction, and the balance between LPO and antioxidant defenses

Background: Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidated. The aim of the study was the evaluation of oxidative stress markers in blood from patients with OJ and its relation to complications and benign/malignant evolution of cholestasis. Methods: A prospective cross-sectional study of 105 patients with OJ and 34 control subjects were included. Several markers of liver function and oxidative stress, such as lipoperoxides (LPO), as well as reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were assessed. Results: The patients with OJ showed a marked increase in plasma levels of LPO, SOD and GSH, while GSH-Px levels were decreased. The increase in lipid peroxidation products and the depletion of SOD activity in blood were also related to renal dysfunction. The highest level of LPO was associated with malignant etiology of the disease. The logistic regression analysis showed that the age of the patient and the levels of LPO in blood were predictors of renal dysfunction in OJ patients. Conclusions: This study demonstrates a correlation between oxidative stress and renal dysfunction patients with OJ.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Redox Biology - Volume 8, August 2016, Pages 160–164
نویسندگان
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