کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1922965 1535848 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory metabolites of vitamin E and their putative relevance for atherogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Regulatory metabolites of vitamin E and their putative relevance for atherogenesis
چکیده انگلیسی


• Macrophage recruitment, proliferation and transformation into foam cells trigger atherosclerosis.
• α-Tocopherol acts as an anti-atherogenic agent in vitro but not in vivo.
• α-Tocopherol and α-tocopherol long-chain metabolites modulate macrophage foam cell formation via different pathways.
• α-Tocopherol long-chain metabolites modulate cellular processes at lower concentrations than α-tocopherol.
• α-Tocopherol long-chain metabolites occur in human plasma and may represent a new class of regulatory metabolites.

Vitamin E is likely the most important antioxidant in the human diet and α-tocopherol is the most active isomer. α-Tocopherol exhibits anti-oxidative capacity in vitro, and inhibits oxidation of LDL. Beside this, α-tocopherol shows anti-inflammatory activity and modulates expression of proteins involved in uptake, transport and degradation of tocopherols, as well as the uptake, storage and export of lipids such as cholesterol. Despite promising anti-atherogenic features in vitro, vitamin E failed to be atheroprotective in clinical trials in humans. Recent studies highlight the importance of long-chain metabolites of α-tocopherol, which are formed as catabolic intermediate products in the liver and occur in human plasma. These metabolites modulate inflammatory processes and macrophage foam cell formation via mechanisms different than that of their metabolic precursor α-tocopherol and at lower concentrations. Here we summarize the controversial role of vitamin E as a preventive agent against atherosclerosis and point the attention to recent findings that highlight a role of these long-chain metabolites of vitamin E as a proposed new class of regulatory metabolites. We speculate that the metabolites contribute to physiological as well as pathophysiological processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Redox Biology - Volume 2, 2014, Pages 495–503
نویسندگان
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