Role of sulfiredoxin in systemic diseases influenced by oxidative stress

• Sulfiredoxin alleviates oxidative burden in various cell types.
• Sulfiredoxin contributes to the pathogenesis of oxidative stress mediated diseases.
• Influencing factors and the parameters influenced by sulfiredoxin are reviewed.

Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress. A myriad of systemic disorders have oxidative stress and reactive oxygen species as the key components in their etiopathogenesis. Recent studies have evaluated the role of this enzyme in oxidative stress mediated diseases such as atherosclerosis, chronic obstructive pulmonary disease and a wide array of carcinomas. Its action is responsible for the normal functioning of cells under oxidative stress and the promotion of cell survival in cancerous cells. This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions.

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