Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells

The schematic diagram shows that total cellular and apical membrane NOX5 proteins are greater than the other NOX proteins (NOX1, NOX2, and NOX4) in human renal proximal tubule (RPT) cells from hypertensive subjects. The increase in NOX5 expression is associated with increased reactive oxygen species production in these RPT cells. We suggest that the increased expression of NOX5, which is, in part, due to increased transcription, may be responsible for the increased oxidative stress in RPT cells in human essential hypertension.