کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1923395 1048890 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunolocalization of FGF7 (KGF) in the regenerating tail of lizard suggests it is involved in the differentiation of the epidermis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Immunolocalization of FGF7 (KGF) in the regenerating tail of lizard suggests it is involved in the differentiation of the epidermis
چکیده انگلیسی
Previous studies showed that Fibroblast Growth Factors (FGF) 1 and 2 are localized in the tissues of the regenerating tail in lizards. In the present immunofluorescence and immunoblotting study we have specifically analyzed the presence and distribution of FGF7 (keratinocyte growth factor) in the regenerating tissues of the tail. FGF7 immunoreactivity is mainly detected in the regenerating epidermis and in sparse fibroblasts of the underlying dermis of the regenerating scales while it is weaker in the other tissues such as the apical ependymal cells and early regenerating muscles. Immunolabeled mesenchymal fibroblasts are frequently present under the epidermis of the forming outer scale surface, a localization that might be connected to beta-cell differentiation in this region of the scale. FGF7 immunolabeling is also seen in differentiating beta-keratinocytes of the beta-layer in the regenerating scales. The present immunofluorescent observations suggest that FGF7 is specifically utilized as a paracrine factor during the process of differentiation of the epidermal layers in the regenerating scales and in particular for beta-cells differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 117, Issue 8, October 2015, Pages 718-724
نویسندگان
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