کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1923535 1048899 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distribution of PCP4 protein in the forebrain of adult mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Distribution of PCP4 protein in the forebrain of adult mice
چکیده انگلیسی

Purkinje-cell protein 4 (PCP4) is a small calmodulin (CaM)-binding protein that has been discovered to be selectively expressed by cerebellar Purkinje cells in the adult rodent brain. In addition, expression of PCP4 mRNA has been detected in the hippocampus and in the cortex. In order to determine the expression of PCP4 protein in the brain, we performed an immunohistochemical analysis using adult mice. We could demonstrate that PCP4 is expressed in neocortical structures, especially in the deep layers, as well as in other cortical structures and parts of the hippocampal formation. Moreover, PCP4 protein is highly expressed in the olfactory bulb and caudate putamen. PCP4 positive cells were also detected in specific areas of the amygdala, thalamus (especially dorsal lateral geniculate nucleus) and hypothalamus. By performing double-labeling experiments together with NeuN (a neuronal marker), we could demonstrate that PCP4 expressing cells in the brain are of neuronal origin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 116, Issue 6, July 2014, Pages 1056–1061
نویسندگان
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