کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1923539 1048899 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-related changes in the optic nerve of Sprague-Dawley rats: An ultrastructural and immunohistochemical study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Age-related changes in the optic nerve of Sprague-Dawley rats: An ultrastructural and immunohistochemical study
چکیده انگلیسی

The optic nerve is a unique part of the central nervous system. It lacks neuronal cell bodies and consists of axons of the retinal ganglion cells together with the supporting neuroglial cells. In the present study, aging of the optic nerve was studied in female Sprague-Dawley rats aged 3, 12, 24 and 30 months old, ultrastructurally, immunohistochemically and morphometrically trying to answer the question why aging is a common risk factor for many ocular diseases especially glaucoma. Additionally, studying the optic nerve aging offered a good opportunity to gain further insight into the effects of aging on white matter. Both nerve fibers and neuroglial cells demonstrated several age related changes which were more profound in 30 months old rats. Optic nerve axons displayed watery degeneration and dark degeneration. Myelin disturbances including widening, whorls, splitting and vacuolations of the myelin lamellae were also observed. Neuroglial cells appeared to be more frequent than in younger rats especially microglia cells and developed dense cytoplasmic inclusions. GFAP-positive astrocytes delineated age-related progressive increase in number, size as well as length and thickness of their processes. CD68 immunohistochemical staining revealed age-related changes in the morphology, location and number of CD68 positive microglia cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 116, Issue 6, July 2014, Pages 1085–1095
نویسندگان
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