کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1923912 1048921 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat
چکیده انگلیسی

SummaryIt is currently believed that portal hypertension induces an inflammatory response in which mast cells may be involved. The aim of this study was to verify the involvement of the intestinal submucosal and mesenteric lymph node mast cells in the splanchnic inflammatory response related to portal hypertension. Mast cell infiltration in the intestine (duodenum, jejunum, ileum, caecum and distal colon) and in the mesenteric lymph node complex (MLC) was measured using a stereological method in sham-operated rats (SO; n=12), in two experimental models of portal hypertension, chronic (triple partial portal vein ligation, TPVL; n=12) and transient (microsurgical partial hepatectomy; n=12) and in rats in which the MLC was resected (n=12). The small and large bowel submucosal infiltration increases in MLC-resected rats (p=0.0001), in TPVL rats (p=0.0001) and in rats with partial hepatectomy (p=0.0001). An extensive mast cell infiltration in the MLC (p=0.0001) was found in TPVL rats and in rats with partial hepatectomy (347.40±45.25 and 351.92±99.28/mm3, respectively) in relation to sham-operated rats (135.27±30.28/mm3). We conclude that mast cells could be involved in the splanchnic alterations developed in the surgical experimental models of portal hypertension studied.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 112, Issue 4, July 2010, Pages 372–382
نویسندگان
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