کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1923998 | 1048928 | 2010 | 9 صفحه PDF | دانلود رایگان |
SummaryThe localization of sialic acids and antimicrobial substances in the foot pads of the cat was examined by lectin histochemical and immunohistochemical methods. The lectin binding patterns of the eccrine glands were suggestive of the existence of large concentrations of sialoglycoconjugates that terminated in Siaα2-3Gal1-4GlcNAc. Results were consistent with localization of O-linked (mucin-type) sialoglycoproteins with the Siaα2-6Gal/GalNAc sequence in the epidermal layers, especially the stratum spinosum. Additionally, antimicrobial peptides, such as lysozyme, secretory component, lactoferrin, and the peptide group of β-defensins were demonstrated to be immunolocalised in the eccrine glandular cells. These substances, except for secretory component, were also distributed in the epidermal strata. The sialic acids and antimicrobial substances found in the eccrine glandular secretions and epidermis may play an essential role in the preservation of skin integrity in feline foot pads.
Journal: Acta Histochemica - Volume 112, Issue 2, March 2010, Pages 169–177