کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1924083 | 1048934 | 2007 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunohistochemical study of the reticular and vascular network of mouse lymph node using vibratome sections
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کلمات کلیدی
ECMPBSLYVE1CFUFRCThree-dimensionalThree-dimensional (3D) reconstructionPCCHEVHSPGImmunohistochemistry - ایمونوهیستوشیمیMucosa-associated lymphoid tissue - بافت لنفاوی مرتبط با مخاطMAS - بیشترBlood vessel - رگ خونیfibroblastic reticular cell - سلول مجزا فیبروبلاستیExtracellular matrix - ماتریکس خارج سلولیMalt - مالتPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریGerminal center - مرکز ژرمینالMice - موشHeparan sulphate proteoglycan - هپارین سولفات پروتئگلیکانcolony-forming unit - واحد تشکیل کلنیhigh endothelial venule - ونول اندوتلیوم بالاCapsule - کپسولLymph node - گره های لنفاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunohistochemical study of the reticular and vascular network of mouse lymph node using vibratome sections Immunohistochemical study of the reticular and vascular network of mouse lymph node using vibratome sections](/preview/png/1924083.png)
چکیده انگلیسی
The function of lymph nodes is greatly influenced by their unique microanatomy, in which distinct subpopulations of cells are compartmentalized by a meshwork of reticular cells and fibres, specialized blood and lymphatic vessels and nerves. Using antibodies against extracellular matrix (ECM) proteins (fibronectin, collagen IV and laminin), proteoglycan (perlecan), and a fibroblastic marker (ERTR-7), the distribution and molecular organization of the system of reticular fibres was investigated by three-dimensional (3D) reconstruction methods. Fibronectin, collagen IV and laminin are restricted to reticular fibres and have a similar distribution pattern, whereas perlecan is limited to the vascular system of the lymph node. Various compartments of the lymph node, such as the B-cell follicle, paracortex (including the high endothelial venules and paracortical cord), and medulla have been reconstructed to visualize their vasculature with respect to B and T cells. Since the morphology of lymph nodes may change significantly in pathological conditions, different compartments of reactive lymph node (after low-dose Listeria monocytogenes infection), especially germinal centres, were also investigated. The data presented here should facilitate our understanding of the 3D organization of non-immune cell components of lymph nodes, which is crucial for cell adhesion, migration, activation, and differentiation in normal and pathological conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 109, Issue 1, 1 March 2007, Pages 15-28
Journal: Acta Histochemica - Volume 109, Issue 1, 1 March 2007, Pages 15-28
نویسندگان
Bin Ma, Jadwiga Jablonska, Werner Lindenmaier, Kurt E.J. Dittmar,