کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1924111 | 1048937 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential role of melatonin in DNA damage caused by nitrosourea-induced mammary carcinogenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Mammary carcinogenesis was induced in female Sprague-Dawley rats by exposure to N-methyl-N-nitrosourea (NMU). Animals were kept under constant light conditions to arrest endogenous melatonin synthesis and were fed the same melatonin dosage, since nitrosourea exposure may also induce cellular injury, especially with extensive proliferative activity. The pro-apoptotic effects of the biogenic amine, melatonin, on rat whole blood leukocytes were assessed by alkaline single cell gel electrophoresis (comet) assay. Potential induction of stress due to animal immobilization and its additional effect on DNA damage was studied. The parameters relevant to the degree of DNA damage in groups with chemocarcinogen treatment demonstrated no significant effects as a result of the immobilization. A significant increase in DNA damage after melatonin treatment in NMU-induced carcinogenesis confirms its involvement in the activation of apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 113, Issue 4, July 2011, Pages 423-427
Journal: Acta Histochemica - Volume 113, Issue 4, July 2011, Pages 423-427
نویسندگان
Janka VaÅ¡ková, Monika Kassayová, Ladislav VaÅ¡ko,