کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1941621 1536901 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
ترجمه فارسی عنوان
توسعه آلبومین-sporopollenin بر اساس پلت فرم بارگذاری دوکسوروبیسین به عنوان حامل دارو
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Albumin was immobilized on a various amount of sporopollenin (Sp).
• 0.79 mg of HSA was bounded on 25 mg of sporopollenin.
• DOX have emission at 480 nm and 560 nm of excitation and emission wavelengths.
• 24 μg of the drug was loaded to the HSA immobilized chitosan at 20 mg of sporopollenin.

Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed that binding amount of HSA has been found to be as 285.53 µg to the 25 mg of Sporopolleninin which also bounded 319.76 µM of DOX. Binding of protein and drug to Sp were clarified by SEM, EDX and FT-IR analysis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemistry and Biophysics Reports - Volume 7, September 2016, Pages 201–205
نویسندگان
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