Allometric dependence of the life span of mammal erythrocytes on thermal stability and sphingomyelin content of plasma membranes

Thermal stability of erythrocyte membrane is a measure for its ability to maintain permeability barrier at deleterious conditions. Hence, it could impact the resistance of erythrocytes against detrimental factors in circulation. In this study the thermostability of erythrocyte membranes was expressed by the temperature, Tgo, at which the transmembrane gradient of ion concentration rapidly dissipated during transient heating. Tgo is the inducing temperature of the membrane transition that activated passive ion permeability at hyperhermia causing thermal hemolysis. A good allometric correlation of Tgo to the resistance against thermal hemolysis and the life span of erythrocytes were found for 13 mammals; sheep, cow, goat, dog, horse, man, rabbit, pig, cat, hamster, guinea pig, rat, and mouse. For the same group, the values of Tgo were strictly related to the sphingomyelin content of erythrocyte membranes. The residual ion permeability, P, was temperature activated from 38 to 57 °C with activation energy of 250 ± 15 kJ/mol that strongly differed from that below 37 °C. The projected value of P at 37 °C was about half that of residual physiological permeability for Na+ and K+ that build ground for possible explanation of the life span vs membrane thermostability allometric correlation.