کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1977655 | 1061507 | 2009 | 5 صفحه PDF | دانلود رایگان |
Since the first report of their natriuretic effect on mammalian kidneys the relative influences of natriuretic peptides (NPs) on volume and salt regulation in vertebrates have been debated. As marine osmoconformers, with plasma ionic concentrations similar to seawater, the actions of NPs on hagfishes may provide information on their primordial role. A synthetic natriuretic peptide derived from Eptatretus burgeri (hNP) increased urine production rates in E. cirrhatus at 3 × 10− 8 M. It also contracted afferent branchial and segmental arteries at low concentrations (1 × 10− 10 M) and relaxed them at 3 × 10− 8 M. Thus, hNP has a renal effect and at higher concentrations causes vascular relaxation suggesting a role in volume regulation and the prevention of cardiac overloading. Rat ANP (rANP) stimulated sodium efflux from both isolated, perfused gill pouches and the whole animal. rANP also reduced subcutaneous sinus haematocrit relative to that in the ventral aorta, which is consistent with a vasodilatory role.
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 150, Issue 1, July 2009, Pages 45–49