کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1978158 | 1061529 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of potential mediators of an intestinal brake mechanism on gut motility in Chinook salmon (Oncorhynchus tshawytscha)
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of potential mediators of an intestinal brake mechanism on gut motility in Chinook salmon (Oncorhynchus tshawytscha) Effects of potential mediators of an intestinal brake mechanism on gut motility in Chinook salmon (Oncorhynchus tshawytscha)](/preview/png/1978158.png)
چکیده انگلیسی
Potential humoral factors controlling an intestinal brake mechanism in Chinook salmon were characterised in terms of their effect on frequency and amplitude of spontaneous contractions in gastrointestinal (GI) rings. Concentration-response curves of gut contractility were produced for cholecystokinin-8 (CCK-8), gastrin-1, glucagon-like peptide-1 (GLP-1) and 5-hydroxytryptamine (5-HT) using gut rings from cardiac stomach (CS), pyloric stomach (PY), pyloric sphincter (Psp) and intestine (Int). Calculated log10 molar (M) EC50 values for CCK-8 (n = 7) were: CS - 8.15 ± 0.90, PY - 7.88 ± 0.48, Psp - 8.98 ± 0.68, Int - 8.93 ± 0.64. Log10 M EC50 values calculated for gastrin 1 (n = 7) were: CS - 12.45 ± 0.66, PY - 12.55 ± 0.63, Psp - 9.35 ± 0.78, Int - 12.69 ± 1.12. Log10 M EC50 values calculated for 5-HT (n = 6) were: CS - 4.78 ± 1.05 and Psp - 6.18 ± 1.14. GLP - 1 (n = 4) produced no response in any of the tissues examined. Spontaneous contractions, measured as spikes per minute and the peak force generated were also measured for each hormone-tissue combination. The Psp generated the greatest mass-specific force, with stomach rings generating the least force. Dilutions of serum from fish diagnosed with gastric dilation air sacculitis (GDAS + ve) increased gut contractility compared to controls (GDAS â ve).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 146, Issue 3, September 2007, Pages 343-347
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 146, Issue 3, September 2007, Pages 343-347
نویسندگان
Leonard G. Forgan, Malcolm E. Forster,