کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1978214 1061532 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The newt Triturus carnifex as a model for monitoring the ecotoxic impact of the fungicide thiophanate methyl: Adverse effects on the adrenal gland
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The newt Triturus carnifex as a model for monitoring the ecotoxic impact of the fungicide thiophanate methyl: Adverse effects on the adrenal gland
چکیده انگلیسی

The aims of this study were to propose a bioindicator organism, the newt Triturus carnifex, for the assessment of toxicological impact of thiophanate methyl in the Campania region (Italy) and the possible adverse activity on the adrenal gland. In the acute toxicity study, experimental groups of T. carnifex were exposed to 2.40, 4.80, 9.60 and 19.20 μg/L tap water of thiophanate methyl for 2 days; the LD50 was found to be 9.60 μg/L. To evaluate the effects on the adrenal gland, newts were exposed to a dose of 25% of the LD50 2 days for 8 days. The ultrastructural features of the tissues as well as the serum levels of aldosterone, corticosterone, norepinephrine (NE) and epinephrine (E) were evaluated. The number of secretory vesicles in the chromaffin cells appeared significantly decreased, whereas NE and E serum levels appeared strongly increased. Moreover, corticosterone and aldosterone serum levels appeared significantly reduced. The results suggest that: 1) T. carnifex has the features of an ideal bioindicator, due to its high sensitivity to thiophanate methyl, 2) thiophanate methyl acts as endocrine disruptor, affecting the adrenal gland at very low doses, 3) thiophanate methyl may be toxic for nontarget organisms, such as newts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 143, Issue 1, May 2006, Pages 86–93
نویسندگان
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