کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1978219 1061532 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vitellogenic effects of 17β-estradiol in male Chinese loach (Misgurnus anguillicaudatus)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Vitellogenic effects of 17β-estradiol in male Chinese loach (Misgurnus anguillicaudatus)
چکیده انگلیسی

Male Chinese loaches (Misgurnus anguillicaudatus) were exposed to 17β-estradiol (E2) in the ambient water at nominal concentrations of 0.5, 1, 5 and 10 μg/L continuously for 8 weeks using a semi-static system. The gonadosomatic index (GSI), total plasma protein, total plasma calcium, magnesium and zinc, and plasma vitellogenin (Vtg) were determined as test endpoints. Our results indicate no significant changes in the GSI between exposed and control groups (P < 0.05). All exposure concentrations of E2 dramatically induced the production of Vtg within 7 days. The vitellogenic response of male loach was time- and dose-dependent. At higher concentrations of E2 (5 and 10 μg/L), total plasma protein, total plasma calcium, and total plasma magnesium presented a significant time- and dose-dependent increase, and the three parameters were significantly correlated with plasma Vtg. We conclude that Chinese loaches are sensitive to estrogenic compounds and may be chosen as potential sentinel species in field and laboratory studies. In addition, total plasma protein, total plasma calcium, and total plasma magnesium can be used as indirect indicators to predict Vtg levels in estrogenized Chinese loach.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 143, Issue 1, May 2006, Pages 127–133
نویسندگان
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