کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1988921 1540468 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus
چکیده انگلیسی

The transient receptor potential ankyrin 1 (TRPA1) is implicated in the mechanical and cold hyperalgesia following inflammation and nerve injury. Its expression has been presumed to be confined to primary afferent terminals. Here, we show that TRPA1 is expressed in astrocytes in the superficial laminae of the rat trigeminal caudal nucleus by use of electron microscopic immunoperoxidase and immunogold labeling techniques. Immunoreactivity for TRPA1 was consistently observed in somata and process of astrocytes and was weaker than that in presumed nociceptive primary afferent terminals, but increased significantly in the fine process of astrocyte in rats with experimental inflammation of the temporomandibular joint. Thus, we provide ultrastructural evidence that TRPA1 is expressed in astrocytes in the brain stem and propose a novel pathway of its involvement in the central mechanism of inflammatory hyperalgesia.


► TRPA1 immunoreactivity was observed in the astrocyte in the superficial lamina of the trigeminal caudal nucleus.
► TRPA1 expression was increased in the process of the astrocyte following TMJ inflammation.
► These findings suggest an existence of novel pathway of TRPA1 involvement in the central mechanisms of inflammatory hyperalgesia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 45, Issues 1–2, October 2012, Pages 45–49
نویسندگان
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