TRPV1 expression in acupuncture points: Response to electroacupuncture stimulation

► Expression of TRPV1 and nNOS is higher in acupoints and upregulated by EA. ► Co-localization of TRPV1 and nNOS in subepidermal nerve fibers and connective tissue. ► TRPV1 and nNOS in skin acupoints play roles in transduction of acupuncture signals.