Distribution of SRPK1 in human brain

Extensive alternative splicing is observed in the mammalian nervous system providing for protein diversity and specificity to accomplish the complex neuronal functions. Mechanisms underlying neuron specific splicing are not yet well understood. Among the factors regulating splicing of major importance are serine/arginine protein kinases (SRPKs) that phosphorylate SR splicing factors. SRPK1 is known to be expressed in the mammalian central nervous system. The present immunohistochemical study reveals a region- and neuron-specific localization of SRPK1 in human brain. The potential involvement of the kinase in the regulation of alternative splicing of various neuronal proteins is discussed.

► SRPK1 is expressed in human brain in neuron-specific manner and not in glia.
► SRPK1 is expressed in human brain in a region-specific manner.
► SRPK1 is often found overexpressed in pyramidal neurons and Purkinje cells.