کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1989138 | 1063567 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat
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کلمات کلیدی
PAGA13A10VLGDpMeA14A11DLGVTANEVPnOA12XSCPOPTPSCA10dcPSDPSRPVPVMHventral midbrain - midbrain وسترنImmunohistochemistry - ایمونوهیستوشیمیDouble-labeling - برچسب دوگانهperiaqueductal gray - خاکستری پرآبیParadoxical sleep - خواب پارادوکسیکoptic tract - دستگاه نوریDopamine - دوپامینSuperior colliculus - ستارگان برترcerebral peduncle - سیب زمینی مغزیfornix - فورنیکسdecussation of the superior cerebellar peduncle - قطع قاعده مفصلی مخچهmedial lemniscus - لنیزوس مدیاSUM - مبلغNovel environment - محیط زیستzona incerta - منطقه نامشخصlateral hypothalamic area - منطقه هیپوتالاموس جانبیanterior hypothalamic area - منطقه هیپوتالاموس قدامیPosterior hypothalamic area - منطقه هیپوتالاموس پشتیventral tegmental area - ناحیه تگمنتوم شکمیinterpeduncular nucleus - هسته interpeduncularSupramammillary nucleus - هسته SupramammillaryVentromedial nucleus - هسته VentromedialMedial mammillary nucleus - هسته ماملیاری Medialdeep mesencephalic nucleus - هسته مزانستالی عمیقdorsal lateral geniculate nucleus - هسته منشاء جانبی پشتی پشتیdorsomedial hypothalamic nucleus - هسته هیپوتالاموس dorsomedialparaventricular hypothalamic nucleus - هسته هیپوتالاموس پروژستیکventral lateral geniculate nucleus - هسته ژنیکولت جانبی جانبی جناغیHypothalamus - هیپوتالاموسoptic chiasm - چیماس اپتیکیinternal capsule - کپسول داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Formerly believed to contribute to behavioural waking (W) alone, dopaminergic (DA) neurons are now also known to participate in the regulation of paradoxical sleep (PS or REM) in mammals. Indeed, stimulation of postsynaptic DA1 receptors with agonists induces a reduction in the daily amount of PS. DA neurons in the ventral tegmental area were recently shown to fire in bursts during PS, but nothing is known about the activity of the other DA cell groups in relation to waking or PS. To fulfil this gap, we used a protocol in which rats were maintained in continuous W for 3Â h in a novel environment, or specifically deprived of PS for 3 days with some of them allowed to recover from this deprivation. A double immunohistochemical labeling with Fos and tyrosine hydroxylase was then performed. DA neurons in the substantia nigra (A9) and ventral tegmental area (A10), and its dorsocaudal extension in the periaqueductal gray (A10dc), almost never showed a Fos-immunoreactive nucleus, regardless of the experimental condition. The caudal hypothalamic (A11) group showed a moderate activation after PS deprivation and novel environment. During PS-recovery, the zona incerta (A13) group contained a significant number and percentage of double-labeled neurons. These results suggest that some DA neurons (A11) could participate in waking and/or the inhibition of PS during PS deprivation whereas others (A13) would be involved in the control of PS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 39, Issue 4, July 2010, Pages 262-271
Journal: Journal of Chemical Neuroanatomy - Volume 39, Issue 4, July 2010, Pages 262-271
نویسندگان
Lucienne Léger, Emilie Sapin, Romain Goutagny, Christelle Peyron, Denise Salvert, Patrice Fort, Pierre-Hervé Luppi,