کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1989295 1063580 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
G proteins in rat prefrontal cortex (PFC) are differentially activated as a function of oxygen status and PFC region
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
G proteins in rat prefrontal cortex (PFC) are differentially activated as a function of oxygen status and PFC region
چکیده انگلیسی

This study tested the hypothesis that activation of guanine nucleotide binding (G) proteins in rat prefrontal cortex (PFC) is altered by hypoxia. G protein activation by the cholinergic agonist carbachol and the opioid agonist DAMGO was quantified using [35S]GTPγS autoradiography. G protein activation was expressed as nCi/g tissue in the PFC of 18 rats exposed for 14 consecutive days to sustained hypoxia (10% O2), intermittent hypoxia (10% and 21% O2 alternating every 90 s), or room air (21% O2). Relative to basal levels of G protein activation, carbachol and DAMGO increased G protein activation by approximately 70% across all oxygen concentrations. Compared to the room air condition, sustained hypoxia caused a significant increase in G protein activation in frontal association (FrA) region of the PFC. Region-specific comparisons revealed that intermittent and sustained hypoxia caused greater DAMGO-stimulated G protein activation in the FrA than in the pre-limbic (PrL). The data show for the first time that hypoxia increased G protein activation in PFC. The results suggest the potential for hypoxia-induced enhancements in G protein activation to alter PFC function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 37, Issue 2, March 2009, Pages 112–117
نویسندگان
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