کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2006040 | 1541727 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of ghrelin on chronic liver injury and fibrogenesis in male rats: Possible role of nitric oxide
ترجمه فارسی عنوان
اثر گرلین بر آسیب مزمن کبدی و فیبروژنز در موش های صحرایی نر: نقش احتمالی اکسید نیتریک
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کلمات کلیدی
eNOSMDAGHSPI3-kinase/AktCLiCCl4ALTNOSBcl-2l-NAME - L-NAMEAST - آسپارتات ترانس آمینازaspartate transferase - آسپارتات ترانسفرازChronic liver injury - آسیب مزمن کبدیalanine transferase - آلانین ترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییBax - باکسendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالB-cell lymphoma 2 - لنفوم سلول B 2malondialdehyde - مالون دی آلدهیدNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازBcl-2-associated X protein - پروتئین X مرتبط با Bcl-2Carbon tetrachloride - کربن تتراکلریدgrowth hormone secretagogue receptor - گیرنده ترشح هورمون رشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Recent studies have revealed that ghrelin may be an antioxidant and anti-inflammatory agent in many organs, however its role in chronic liver injury (CLI) remains unclear. The role of nitric oxide (NO) in CLI is controversial as evidence suggests that NO is either a primary mediator of liver cell injury or exhibits a protective effect against injurious stimuli. Recent evidence demonstrated that the therapeutic potential for ghrelin was through eNOS activation and increase in NO production. However, its role on NO production in the liver has not been previously investigated. The aim of this study was to investigate the role of ghrelin in treatment of CLI, and whether this action is mediated through NO. Forty male rats were divided into four groups: Group I: Control; Group II: chronic liver injury (CLI); Group III: CLI + Ghrelin; and Group IV: CLI + Ghrelin + l-NAME. Liver enzymes and tumor necrosis factor alpha (TNF-α), were measured to assess hepatocellular injury. Liver tissue collagen content, malondialdehyde (MDA), gene expression of Bax, Bcl-2, and eNOS were assessed to determine the mechanism of ghrelin action. Results showed that ghrelin decreased serum liver enzymes and TNF-α levels. Ghrelin also reduced liver tissue collagen, MDA, and Bax gene expression, and increased Bcl-2 and eNOS gene expression. The effects on TNF-α, collagen, MDA, Bax, and eNOS were partially reversed in Group IV, suggesting that ghrelin's action could be through modulation of NO levels. Therefore, ghrelin's hepatoprotective effect is partially mediated by NO release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 52, February 2014, Pages 90-97
Journal: Peptides - Volume 52, February 2014, Pages 90-97
نویسندگان
Nashwa N. Kabil, Hanan A. Seddiek, Nadia A. Yassin, Maha M. Gamal-Eldin,