کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2006198 | 1541731 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of recombinant trout leptin in superoxide production and NF-κB/MAPK phosphorylation in blood leukocytes
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کلمات کلیدی
NF-κBIL-12CD4CD8ERKIL-6Jnkc-Jun N-terminal kinase - C-Jun N-terminal kinaseERK1/2 - ERK1 / 2MAPK - MAPKp38 MAP kinase - p38 mAP kinasesuperoxide anion - آنیون سوپر اکسیدinterleukin 12 - اینترلوکین 12interleukin 6 - اینترلوکین 6tumor necrosis factor alpha - تومور نکروز عامل آلفاCluster of differentiation 4 - خوشه تمایز 4Signaling - سیگنالینگTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استLeptin - لپتین extracellular signal-regulated kinase 1/2 - کیناز 1/2 تنظیم سیگنال خارج سلولیextracellular-signal-regulated kinase - کیناز تنظیم شده خارج سلولی سیگنالmitogen-activated protein kinases - کیناز پروتئین فعال Mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Studies in mammals indicate that leptin is a multifunctional cytokine involved in regulation of energy metabolism and the modulation of the immune function. However, evidence for an immunomodulatory effect of leptin in fish is still missing. At least in part, this lack of knowledge is due to the absence of materials and models. In this study, we produced trout recombinant leptin (rt-lep) and tested its capacity to trigger cellular pathways, usually active in mammal immune system cells. STAT3, NF-κB, and the three major MAPK cascades (JNK, p38 and ERK), were activated by rt-lep in in vitro incubations with blood leucocytes of the rainbow trout Oncorhynchus mykiss. We also showed that rt-lep causes a decrease in superoxide anion production in trout blood leucocytes. Thus our data indicate that as in mammals also in teleosts leptin plays pleiotropic activities. Importantly, its actions in fishes do not always conform to the picture emerging for mammals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 48, October 2013, Pages 59-69
Journal: Peptides - Volume 48, October 2013, Pages 59-69
نویسندگان
Giovanna Mariano, Romania Stilo, Giuseppe Terrazzano, Elena Coccia, Pasquale Vito, Ettore Varricchio, Marina Paolucci,