کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2006277 1541740 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica
چکیده انگلیسی

Antimicrobial peptides (AMPs) are important components of the innate immunity. Many antimicrobial peptides have been found from marine mollusks. Little information about AMPs of mollusks living on land is available. A novel cysteine-rich antimicrobial peptide (mytimacin-AF) belonging to the peptide family of mytimacins was purified and characterized from the mucus of the snail of Achatina fulica. Its cDNA was also cloned from the cDNA library. Mytimacin-AF is composed of 80 amino acid residues including 10 cysteines. Mytimacin-AF showed potent antimicrobial activity against Gram-negative and Gram-positive bacteria and the fungus Candida albicans. Among tested microorganisms, it exerted strongest antimicrobial activity against Staphylococcus aureus with a minimal peptide concentration (MIC) of 1.9 μg/ml. Mytimacin-AF had little hemolytic activity against human blood red cells. The current work confirmed the presence of mytimacin-like antimicrobial peptide in land-living mollusks.


► A novel antimicrobial peptide (mytimacin-AF) was purified and characterized from the mucus of the snail, Achatina fulica.
► Mytimacin-AF was a cysteine-rich antimicrobial peptide belonging to the peptide family of mytimacins.
► Mytimacin-AF showed potent antimicrobial activities against Gram-negative and -positive bacteria and the fungus.
► The current work confirmed the presence of mytimacin-like antimicrobial peptide in land-living mollusks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 39, January 2013, Pages 1–5
نویسندگان
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