Effect of human beta-defensin-3 on the proliferation of fibroblasts on periodontally involved root surfaces

► HBD-3 showed no toxic effects to PDL cells up to 200 ng/ml. ► HBD-3 improved PDL fibroblasts attachment and proliferation onto the periodontitis affected root surfaces. ► HBD-3 may act as a potent regeneration-promoter in infected diseases.