کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2006795 1066354 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues
چکیده انگلیسی

Ghrelin is an endogenous ligand of the type 1a growth hormone secretagogue receptor (GHSR1a) that regulates energy balance. Ghrelin and obestatin, derived from the post-translational processing of preproghrelin, are involved in a diverse range of biological activities, yet their effect on the immune system is not fully understood. In the present study, we investigated the roles of ghrelin and obestatin on mast cell degranulation and found that both ghrelin and obestatin induce the release of histamine from rat peritoneal mast cells. This induced histamine release was inhibited by the pertussis toxin, an inhibitor of Gαi protein, and extracellular Ca2+. Rat peritoneal mast cells and rat basophilic leukemia (RBL-2H3) cells did not express the ghrelin receptor GHSR1a, suggesting that histamine release induced by ghrelin occurs via a receptor-independent mechanism. We report here that ghrelin and obestatin, belonging to the family of basic secretagogues, stimulate mast cells independent of a receptor, and this may play a crucial role at the site of allergy or inflammation.

Research highlights▶ Ghrelin and obestatin induce histamine release from mast cells as basic secretagogues. ▶ Ghrelin- and obestatin-induced histamine release is mediated via Gαi. ▶ Ghrelin stimulates mast cells independent of GHSR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 31, Issue 11, November 2010, Pages 2109–2113
نویسندگان
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