کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2007361 | 1066372 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel physiological property of snake bradykinin-potentiating peptides—Reversion of MK-801 inhibition of nicotinic acetylcholine receptors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A novel physiological property of snake bradykinin-potentiating peptides—Reversion of MK-801 inhibition of nicotinic acetylcholine receptors A novel physiological property of snake bradykinin-potentiating peptides—Reversion of MK-801 inhibition of nicotinic acetylcholine receptors](/preview/png/2007361.png)
چکیده انگلیسی
The first naturally occurring angiotensin-converting enzyme (ACE) inhibitors described are pyroglutamyl proline-rich oligopeptides, found in the venom of the viper Bothrops jararaca, and named as bradykinin-potentiating peptides (BPPs). Biochemical and pharmacological properties of these peptides were essential for the development of Captopril, the first active site-directed inhibitor of ACE, currently used for the treatment of human hypertension. However, a number of data have suggested that the pharmacological activity of BPPs could not only be explained by their inhibitory action on enzymatic activity of somatic ACE. In fact, we showed recently that the strong and long-lasting anti-hypertensive effect of BPP-10c [
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 29, Issue 10, October 2008, Pages 1708–1715
Journal: Peptides - Volume 29, Issue 10, October 2008, Pages 1708–1715
نویسندگان
Arthur A. Nery, Cleber A. Trujillo, Claudiana Lameu, Katsuhiro Konno, Vitor Oliveira, Antonio C.M. Camargo, Henning Ulrich, Mirian A.F. Hayashi,