کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007526 1066377 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues
چکیده انگلیسی

Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 28, Issue 5, May 2007, Pages 1129–1143
نویسندگان
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