کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2007871 | 1066388 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro activity of the synthetic lipopeptide PAL-Lys-Lys-NH2 alone and in combination with antifungal agents against clinical isolates of Cryptococcus neoformans
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro activity of the synthetic lipopeptide PAL-Lys-Lys-NH2 alone and in combination with antifungal agents against clinical isolates of Cryptococcus neoformans In vitro activity of the synthetic lipopeptide PAL-Lys-Lys-NH2 alone and in combination with antifungal agents against clinical isolates of Cryptococcus neoformans](/preview/png/2007871.png)
چکیده انگلیسی
The in vitro activity of the lipopeptide PAL-Lys-Lys-NH2 (PAL), alone or combined with either fluconazole (FLU) or amphotericin B (AMB), was investigated against 14 Cryptococcus neoformans isolates. PAL MICs ranged from 1.0 to 4.0 μg/ml. Fungicidal activity was observed. Synergy, defined as a fractional inhibitory concentration (FIC) index of â¤0.5, was observed in 21.4% of PAL/AMB interactions. Antagonism (FIC index > 4) was never observed. The broad antifungal activity and the positive interactions with AMB suggest that PAL can represent a promising candidate in infections due to C. neoformans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 28, Issue 8, August 2007, Pages 1509-1513
Journal: Peptides - Volume 28, Issue 8, August 2007, Pages 1509-1513
نویسندگان
Francesco Barchiesi, Andrea Giacometti, Oscar Cirioni, Daniela Arzeni, Carmela Silvestri, Wojciech Kamysz, Alessandra Abbruzzetti, Alessandra Riva, Elzbieta Kamysz, Giorgio Scalise,