کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008088 1066396 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intrathecal CART (55–102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Intrathecal CART (55–102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain
چکیده انگلیسی

CART peptides are found in brain and spinal cord areas involved in pain transmission. In the present study, we investigated the role of rat CART (55–102) in the modulation of chronic pain using models of chronic neuropathic (nerve injury model) and inflammatory (carrageenan test) pain models in the mouse after intrathecal administration. The results show that CART (55–102) was highly effective in reversing the hyperalgesia and allodynia signs of chronic neuropathic pain in a dose-related manner at doses (0.05–2 μg/mouse) that did not affect motor coordination of the animals. These effects lasted for at least 3 h after injection and were not blocked by naloxone, an opiate antagonist. Although CART (55–102) attenuated carrageenan-induced hyperalgesia, it failed to reduce the inflammation associated with this model. These results suggest the involvement of the CART peptides in the development of hyperalgesia and allodynia associated with neuropathic pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 8, August 2006, Pages 2019–2023
نویسندگان
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