کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008240 1066401 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure
چکیده انگلیسی

Although urocortin 1 (Ucn-1) has been reported to circulate in human plasma and be raised in heart failure, little, if any, information is available regarding the source of circulating Ucn-1. Accordingly, we have performed trans-organ arteriovenous sampling for measurement of Ucn-1 concentration in anesthetized sheep before and after development of pacing-induced heart failure. Arterial plasma Ucn-1 levels measured 15.2 ± 0.5 pmol/L in normal sheep and increased significantly following development of heart failure to 19.1 ± 1.6 (p < 0.05). Small but significant positive arteriovenous gradients were observed across the hepatic and renal tissue beds in both states, with rises across the hind limb significant in normal animals and across the head in heart failure. This is the first report identifying sources of circulating Ucn-1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 7, July 2006, Pages 1801–1805
نویسندگان
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