A study on low dose cypermethrin induced histopathology, lipid peroxidation and marker enzyme changes in male rat

The short term effect of low dose synthetic pyrethroid and insecticide α-cypermethrin was investigated in selected tissues of male albino Wistar strain rats. Cellular antioxidant activities, specific enzyme markers and tissue histopathology were studied using this compound at 5, 10, 25 and 50 mM at given time points during independent experiments. α-Cypermethrin was administered intradermally. Selective tissue responses were determined 6 h post administration employing control and experimental animals using established methods. Different doses of α-cypermethrin increased the malondialdehyde (MDA) content in the brain, heart, liver, kidney and testis of the male rats. Alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) enzyme activity levels were altered in these tissues and in the serum. Cytotoxic effects produced by α-cypermethrin were reflected in histopathology sections of the treated tissues. α-Cypermethrin decreased the cellular antioxidant activity, altered marker enzyme activity and effected histopathological changes in the treated animal tissues.