کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2011792 1067015 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nano-mechanical model of endothelial dysfunction for AFM-based diagnostics at the cellular level
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Nano-mechanical model of endothelial dysfunction for AFM-based diagnostics at the cellular level
چکیده انگلیسی
A review of recent experimental investigations on the nanomechanical response of individual endothelial cells to inflammation caused by environmental agents and selected chemical compounds is presented. We focus on the results obtained by means of the force spectroscopy using the tip of an atomic force microscope as an imaging and nanoindentation spectroscopic probe. The findings presented in this review allow validating the nanoindentation method as a tool for quantitative cell elasticity probing and thereby allow proposing a nanomechanical model of endothelial dysfunction that could be practically used for drug efficacy and toxicity profiling in the endothelium at the subcellular level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 67, Issue 4, August 2015, Pages 728-735
نویسندگان
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