کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2012071 1067023 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population
چکیده انگلیسی

The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as a gate-keeper against various kinds of xenobiotics. Several single nucleotide polymorphisms (SNPs) in the MDR1 gene that may influence PGP level and function have been identified. The aim of this study was to simultaneously analyze the three most important MDR1 SNPs, C3435T, G2677T/A and C1236T, in the Serbian population and to compare the results with those published for other ethnic groups. A group of 158 unrelated, healthy subjects was included in the present study. For determination of MDR1 SNPs, a multiplexed mutagenically separated PCR was performed. The genotype frequency of the analyzed MDR1 SNPs was as follows: 3435 nt – 0.19 (CC), 0.54 (CT) and 0.27 (TT); 2677 nt – 0.26 (GG), 0.52 (GT), 0.15 (TT), 0.03 (GA) and 0.064 (TA), and 1236 nt – 0.23 (CC), 0.61 (CT) and 0.16 (TT). Our results for the Serbian population could be relevant for further investigation of drugs that are substrates of PGP and for studies of interethnic diversity in MDR1 polymorphism frequency.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 63, Issue 3, May–June 2011, Pages 808–814
نویسندگان
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