کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2012132 | 1067025 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Strong antioxidant activity of carane derivatives
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Oxidants play a significant role in causing oxidative stress, which underlies the pathogenesis of inflammation and rheumatoid arthritis. The processes associated with inflammatory responses are complex and often involve reactive oxygen species. There are many mediators that initiate and amplify the inflammatory response such as histamine, serotonin and metabolic products of arachidonic acid (thromboxane, prostaglandins and leukotrienes). In the present study, we examined the antioxidant activity of carane derivatives - KP-23 and its optical isomers - that possess strong local anesthetic and anti-inflammatory activity. The antioxidant effects (expressed as Trolox Equivalent Antioxidants Capacity, TEAC) were observed for one of the optical isomers of carane, a derivative of propranolol - KP-23R. The relative scavenging effect (%R) of ABTS+ by KP-23S, KP-23R and standards measured at 30Â min was the following, listed in decreasing order: tetracaine > KP-23S > KP-23R > procaine > lignocaine > benzocaine (99, 85, 80, 38, 21 and 20%, respectively, at a concentration of 10Â mM). The IC50 values also show strong antioxidant properties of the investigated KP compounds (ranging between 11-18Â mM) and tetracaine (6.2Â mM) compared to other local anesthetics (129-348Â mM). Moreover, monoterpene derivatives were more effective as antioxidants than propranolol diastereoisomers (280-528Â mM). We found that carane derivatives, in contrast to propranolol diastereoisomers, serve as potent antioxidants by scavenging radicals
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 62, Issue 1, JanuaryâFebruary 2010, Pages 178-184
Journal: Pharmacological Reports - Volume 62, Issue 1, JanuaryâFebruary 2010, Pages 178-184
نویسندگان
Tadeusz Librowski, Andrzej Moniczewski,