Synthesis and biological evaluation of 3β-androsta-5,8(14),15-trien-17-one derivatives as potential anticancer agents

• (3β) 16-Arylandrostatrien-17-ones were from dehydroepiandrosterone.
• 16-Arylandrostatrien-17-ones combined 16-arylandroster-17-one with extended conjugated system via Δ8,14 and Δ15,16 moieties.
• (3β) 16-Arylandrostatrien-17-ones showed cytotoxicity against cancer cell lines.

A novel and operationally simple method for highly efficient synthesis of promising anti-cancer 3β-hydroxy-16-arylandrosta-5,8(14),15-trien-17-ones was reported. Compounds were tested for their cytotoxic activities against A549, SKOV3, MKN-45 and MDA-MB-435 cancer cell lines. The preliminary results showed that compounds 5e, g were the most active especially against cancer cell lines tested.

The efficient synthesis of some androsta-5(6),8(14),15(16)-trien-17-one derivatives was investigated. The synthesized compounds showed significant anticancer activity against A549, SKOV3, MKN-45 and MDA-MB-435 cell lines.Figure optionsDownload as PowerPoint slide