کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2027609 1542698 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
First synthesis of 22-oxa-chenodeoxycholic acid analogue
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
First synthesis of 22-oxa-chenodeoxycholic acid analogue
چکیده انگلیسی


• We have firstly succeeded in synthesizing the 22-oxa-CDCA analogue from androstenedione and progesterone, respectively.
• The synthesis was achieved in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively.
• This study provides an access towards the development of CDCA analogues as new drugs.

In this study, we report the first synthesis of 22-oxa-chenodeoxycholic acid analogue via androstenedione and progesterone, in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively. We anticipate this will help to facilitate the development of new drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 110, June 2016, Pages 70–76
نویسندگان
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