Govanoside A, a new steroidal saponin from rhizomes of Trillium govanianum

• Trillium govanianum rhizomes is rich in steroidal saponins.
• Report of a new steroidal saponin, Govanoside A from T. govanianum and identification of three already known steroids.
• First time, report of antifungal activity of Govanoside A and borassoside E.
• Significant impact of isolated compounds against pathogenic filamentous fungi and yeast.

A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trillium and all compounds (1–4) in T. govanianum are reported herein for the first time. Furthermore, compounds 1 & 2 exhibited good to moderate activities against Aspergillus niger ATCC 16888, Aspergillus flavus ATCC 9643, Candida albicans ATCC 18804, and Candida glabrata ATCC 90030. This is a significant finding keeping in view the limited antifungal drugs for aspergillosis and candidiasis.