Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes

• The lanostane derivatives of the Vietnamese Penares sp. were investigated.
• Eight new oxidated triterpenoids were isolated and structurally described.
• The biogenetic correlation of triterpene metabolites in Penares and Erylus spp. was discussed.

Eight new oxidized lanostane and nor-lanostane derivatives (1–8) along with the previously known penasterol (9) and 24-ethylcholesta-4,24(28)-dien-3-one (10) were isolated from a sponge Penares sp. collected from the Vietnamese waters. Structures of these minor compounds were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses and by comparison with earlier reported spectroscopic data. A hypothetic scheme of metabolism of the lanostane derivatives in sponges belonging to Penares and Erylus genera was proposed and discussed.

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