کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2027853 | 1542713 | 2015 | 6 صفحه PDF | دانلود رایگان |
• This way shows a new approach for the allylic oxidation of Δ5-steroids.
• This way shows the reaction of t-butyl hydroperoxide with Δ5-steroids in the presence of N-hydroxyphthalimide.
• This way show excellent regioselectivity and chemoselectivity.
• The reaction mechanism and the scope of the reaction were investigated.
A new and optimized procedure for the allylic oxidation of Δ5-steroids with t-butyl hydroperoxide in the presence of catalytic amounts of N-hydroxyphthalimide (NHPI) under mild conditions was developed, showing excellent regioselectivity and chemoselectivity (functional group compatibility). It was found that Co(OAc)2 could enhance the catalytic ability of NHPI resulting in better yields and shorter reaction times. The reaction mechanism and the scope of the reaction with a variety of Δ5-steroidal substrates were also investigated.
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Journal: Steroids - Volume 94, February 2015, Pages 1–6